Pharmacology of non sedating antihistamines sexy dating headlines

However, pregnant women must be warned about the other aspects of safety such as sedation and consider whether they should not drive while taking these drugs.The newer antihistamines are likely to be as safe in pregnancy but have not been used by as many women, so they do not have the same evidence of safety.Allergic rhinitis refers to nasal inflammation due to the release of histamine and other mediators from Ig E-mediated mast cell degranulation in the nose.Other conditions may cause similar symptoms, but they can be distinguished from allergic rhinitis by allergy testing to confirm positive allergen-specific Ig E to specific triggers.

Some antihistamines are used for their antinausea or sedative Loratadine is metabolised in the liver, while cetirizine, desloratadine and fexofenadine are not metabolised extensively.

They are particularly useful for nasal itchiness, sneezing and rhinorrhoea, but are less effective for nasal obstruction.

Oral antihistamines also have the benefit of treating associated conjunctival symptoms.

However, for promethazine there is a risk of severe tissue injury, including gangrene, with both intramuscular and intravenous administration.

The main role for sedating antihistamines is in pregnancy, where they can be used for any of the common indications for antihistamines, as they have the strongest evidence of safety.

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Sedating antihistamines can also have anticholinergic effects that can be particularly problematic in older patients who are more susceptible to adverse effects such as dry mouth, urinary retention and delirium.

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